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Chemo Drugs

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Busulfan (Myleran)

What Does It Look Like?

White tablet

How Is It Given?

Oral (by mouth)

Why Am I Taking It?

Busulfan in an anti-cancer drug that stops cell growth and division. It is used to treat leukemia.

What Side Effects May Occur?

You may experience some, all, or none of those listed. Most side effects do not last long. Tell the doctor or nurse about any that you experience. The information here does not include all possible side effects; others may occur. Please report problems to your doctor.

Low Blood Counts

  • A drop in blood cell counts, especially white blood cells, occurs within 2-4 weeks after starting treatment.
  • Blood tests will be done to check your blood counts. Tell your doctor about any signs of infection or bleeding. Avoid situations where you might be exposed to people with infections.

Skin Changes

  • Darkening of the skin, especially in the area of creases, commonly occurs.
  • Swelling of the feet or lower legs may occur.
  • Mouth sores may develop. Inspect your mouth daily. Rinse your mouth after meals and at bedtime with a mild salt water solution. Call the doctor if you notice any sores or bleeding.

Sexual Changes

  • Breast enlargement may occur in men.
  • Menopausal symptoms may occur in women.

Nausea, Vomiting, Appetite Loss

  • May experience nausea, vomiting, loss of appetite, diarrhea, and unusual tiredness.
  • Medication will be available to control the nausea and vomiting if they occur.
  • Drink plenty of fluid (2-3 quarts/day) while receiving therapy.

Special Notes:

A rare complication of long term therapy with this drug is damage to the lungs. Symptoms may be a cough and shortness of breath.

Changes in your menstrual cycle or sperm counts may occur. Discuss birth control measures with your doctor as it is not advisable to conceive or to father children while taking this drug.

Use this information in the absence of more specific or personal advice given to you by your doctor, pharmacist or nurse.

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