Chemo Drugs

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Cytoxan (Cyclophosphamide)

What Does It Look Like?

• Clear liquid
• White tablets with blue speckles

How Is It Given?

• Intravenous (vein)
• Oral (mouth)

Why Am I Taking It?

Cytoxan is an anti-cancer drug that stops cell growth and division. It is used to treat several kinds of cancer including leukemia, lymphomas, breast, endometrial, ovarian, and small cell lung cancers; multiple myeloma, and sarcomas or connective tissue cancers.

What Side Effects May Occur?

You may experience some, all, or none of those listed. Most side effects do not last long. Tell the doctor or nurse about any that you notice. The information here does not include all possible side effects; others may occur. Please report any problems to your doctor.

Low Blood Counts

• A drop in blood cell counts, especially white blood cells, occurs about 7-14 days after treatment.
• Blood tests will be done to monitor this. Call your doctor about any signs of bleeding or infection. Avoid situations where you might be exposed to people with infections.

Nausea, Vomiting, Appetite Loss

• Mild to moderate nausea and vomiting may occur within 3-12 hours and can last 8-12 hours. Medication will be available to control these symptoms.
• May experience appetite loss. Drink plenty of fluids, about 2-3 quarts a day.

Hair Loss, Skin Changes

• Some hair loss may occur. This may include head and body hair.
• Hair will grow back after therapy with Cytoxan is finished.
• Increased color of the nails and skin may occur. Ridges may form on the nails.
• May cause sores in your mouth. Inspect your mouth daily. Rinse your mouth after meals and at bedtime with a mild salt water solution.

Bladder Irritation/Bleeding

• Usually avoided with good fluid intake and frequent urination.
• Drink plenty of fluids (at least 2 quarts a day) after therapy.
• Empty your bladder frequently, at the first feeling of needing to urinate.
• Call your doctor if you notice any blood in your urine.

Special Notes

• Oral Cytoxan is generally taken in the morning to make emptying your bladder often more convenient.
• Changes in your menstrual cycle or sperm count may occur. Discuss birth control measures with your doctor as it is not advisable to conceive or to father children while taking this drug.