Chemo Drugs

back to drug index

Etoposide (VP-16, Vepesid)

What Does It Look Like?

Clear liquid; Pale pink capsules

How Is It Given?

Intravenous (vein); Oral (mouth)

Why Am I Taking It?

Etoposide is an anti-cancer drug that stops cell growth and division. It is used to treat leukemia, certain kinds of lung cancer, lymphomas, breast cancer, and cancers of the prostate, testicles, bladder, uterus, muscle and nerves.

What Side Effects May Occur?

You may experience some, all, or none of those listed. Most side effects do not last long. Tell the doctor or nurse about any that you notice. The information here does not include all possible side effects; others may occur. Please report any problems to your doctor.

Low Blood Counts

• A drop in blood cell counts occurs usually about 7-14 days after treatment. Blood tests will be done to check this.
• Call your doctor about any signs of infection or bleeding. Avoid situations where you may be exposed to people with infections.

Nausea, Vomiting, Appetite Loss

• Mild nausea, vomiting, abdominal cramps, loss of appetite and/or diarrhea may occur.
• Medication will be available to control these symptoms.
• Drink plenty of fluids (2-3 quarts per day) after therapy.

Skin Changes

• Skin previously treated with radiation therapy may redden.
• Redness or soreness at the IV site may occur. Tell the nurse immediately if this happens.
• May develop sores in your mouth. Inspect your mouth daily. Rinse your mouth after meals and at bedtime with a mild salt water solution.
• May experience an "after taste" from Etoposide, or changes in taste perception.

Hair Loss

• May affect both head and body hair.
• Hair will grow back after treatment is finished.

Nervous System

• May experience numbness and/or tingling in the fingers and toes.

Allergic Reaction

• May have an allergic reaction shown by fever, chills, shortness of breath, difficulty breathing, wheezing, or low blood pressure.
• Notify the doctor or nurse immediately if any of these symptoms occur.
• Drugs can be prescribed to lessen these symptoms.

Special Notes

• Changes in your menstrual cycle or sperm count may occur. Discuss birth control measures with your doctor as it is not advisable to conceive or to father children while taking this drug.