Chemo Drugs

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Mercaptopurine (Purinethol, 6-Mercaptopurine, 6-MP)

What Does It Look Like?

White tablet

How Is It Given?

Oral (mouth)

Why Am I Taking It?

Mercaptopurine is an anti-cancer drug that stops cells from dividing. This drug is used to treat acute and chronic leukemias.

What Side Effects May Occur?

You may experience some, all, or none of those listed. Most side effects do not last long. Tell the doctor or nurse about any that you notice. The information here does not include all possible side effects; others may occur. Please report any problems to your doctor.

Low Blood Counts

• A drop in blood cell counts, especially white blood cells and platelets, occurs within 2-3 weeks after treatment.
• Tell your doctor about any signs of infection or bleeding.
• Avoid situations where you may be exposed to people with infections when your counts are low.
• Your blood will be drawn at regular intervals to check your blood counts.

Nausea, Vomiting, Mouth Sores

• Occur infrequently. Drugs can be ordered to control these symptoms.
• Frequent care by brushing teeth and rinsing mouth is important. Call your nurse or doctor if soreness develops.
• Rinse your mouth after meals and at bedtime with a mild salt water solution.

Liver Function

• Changes in this organ may occur. Call your doctor if you notice yellowing of the eyes and skin.

Special Notes

• Mercaptopurine may increase the blood thinning effects of Coumadin.
• Changes in your menstrual cycle or sperm count may occur. Discuss birth control measures with your doctor as it is not advisable to conceive or to father children while taking this drug.
• It is important to drink extra liquids to help prevent kidney and bladder problems.
• Avoid alcoholic beverages until you have discussed this with your doctor.