Chemo Drugs

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Mitotane (Lysodren)

What Does It Look Like?

White tablet

How Is It Given?

Oral (mouth)

Why Am I Taking It?

Mitotane is an anti-cancer drug that stops cell growth and division. This drug is used to treat cancer of the adrenal gland.

What Side Effects May Occur?

You may experience some, all, or none of those listed. Most side effects do not last long. Tell the doctor or nurse about any that you notice. The information here does not include all possible side effects; others may occur. Please report any problems to your doctor.

Low Blood Counts

• A drop in blood counts happens rarely.
• Your blood will be checked occasionally to monitor this.
• Call your doctor if you notice any signs of infection or bleeding. Avoid situations where you might be exposed to people with infections.

Nausea, Vomiting, Appetite Loss, Diarrhea

• May cause nausea and vomiting.
• It may help to use anti-nausea medication one half hour before taking the dose.
• It may help to divide daily dosage into 3-4 separate doses.
• Medication may be prescribed to help with diarrhea, nausea, or vomiting if they occur.
• Call your doctor if you notice blood in your stools or if the diarrhea continues.

Skin Changes, Hair Loss

• May cause temporary hair loss.
• A skin rash may occur.

Nervous System

• Mitotane may cause some people to become dizzy, drowsy, or less alert than they are normally.
• Make sure you know how you will react to the medicine before you drive or do other jobs that require you to be alert.

Special Notes

• Mitotane will add to the effects of alcohol and depressant medicines. Check with your doctor before using these drugs.