Chemo Drugs

back to drug index

Plicamycin (Mithracin)

What Does It Look Like?

Clear liquid

How Is It Given?

Intravenous (vein)

Why Am I Taking It?

Plicamycin is an anti-cancer drug that stops cell growth and division. This drug also is used to treat testicular cancer and certain leukemias. This drug also is used to lower high calcium levels.

What Side Effects May Occur?

You may experience some, all, or none of those listed. Most side effects do not last long. Tell the doctor or nurse about any that you notice. The information here does not include all possible side effects; others may occur. Please report any problems to your doctor.

Low Blood Counts

• Low blood counts, especially platelets, occur within 7-10 days after treatment.
• Call your doctor with any signs of infection or bleeding. This bleeding may be nosebleeds, blood in bowels, urine or stomach contents, or easy bruising.
• Avoid situations where you might be exposed to people with infections.
• Your blood will be drawn regularly to check your blood counts.

Nausea, Vomiting, Appetite Loss, Diarrhea, Mouth Sores

• Mouth soreness is possible. Call your nurse or doctor if you have soreness.
• Inspect your mouth daily. Rinse after meals and at bedtime with a mild salt water solution.
• Nausea and vomiting may occur. Anti-nausea medicines will be given before treatment. Nausea usually occurs 1-2 hours after treatment and lasts 12-24 hours.

Hair Loss

• Hair loss is rare with this medication.

Skin Irritation

• May cause tissue damage if it leaks our of the vein.
• Report any stinging or burning at the IV site to your nurse immediately.

Nerve/Muscle Changes

• Call your doctor for muscle cramps, weakness, or tingling/numbness of hands and/or feet.

Special Notes

• Do not take aspirin or other medicines containing aspirin without consulting your doctor.
• Changes in your menstrual cycle or sperm count may occur. Discuss birth control measures with your doctor as it is not advisable to conceive or to father children while taking this drug.